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目的 探讨结肠异时性腺瘤 Bcl- 2和 P53异常表达与病理分型的关系及其临床意义。方法 对 192例初发性息肉样病变应用免疫组化方法检测 Bcl- 2及 P53基因表达。结果 Bcl- 2、P53阳性率在异时性腺瘤比初发性腺瘤明显增高 ,随着肿瘤病理分级增加阳性率上升 ,呈正相关性 (P<0 .0 1)。 Bcl- 2 + / P53+ 组异时性腺瘤发病间期明显缩短 ,较阴性有显著性差异 (P<0 .0 1)。结论 Bcl- 2 + / P53+ 异时性腺瘤发病间期短 ,增殖活性强恶性潜能高。检测此项目可作为判断结肠腺瘤恶性潜能的重要生物学指标。
Objective To investigate the relationship between abnormal expression of Bcl-2 and P53 in colorectal adenoma and its pathological classification and its clinical significance. Methods 192 cases of primary polypoid lesions were detected by immunohistochemistry Bcl-2 and P53 gene expression. Results The positive rates of Bcl-2 and P53 were significantly higher in patients with heterotopic adenomas than those with primary adenomas. The positive rates of Bcl-2 and P53 were positively correlated with the pathological grade (P <0.01). The incidence of heterosexual adenoma in Bcl-2 + / P53 + group was significantly shorter than that in negative group (P <0.01). Conclusions The incidence of Bcl-2 + / P53 + heterotrophic adenoma is short and its proliferation potential is high. Detection of this project can be used as an important biological indicators to determine the malignant potential of colon adenoma.