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目的探索叶下珠、干扰素α-2b(IFNα-2b)不同组方治疗慢性低酶型乙型肝炎的临床治疗效果。方法用叶下珠片治疗低酶型乙型肝炎152例,3个月内ALT升高达1000U/L以上者,随机分为叶下珠继续治疗组(Ⅱa组),加用IFNα-2b组(Ⅱb组),改用IFNα-2b组(Ⅱc组),仍属低酶者设为对照组(Ⅰ组)继续应用叶下珠,Ⅰ组、Ⅱ组所有患者在相同条件下,采用不同方案继续治疗6个月。结果Ⅱa、Ⅱb、Ⅱc组均在ALT复常,HBeAg阴转,抗-HBe阳转,HBVDNA阴转方面优于Ⅰ组(P<0.05);Ⅱb、Ⅱc组明显优于Ⅰ组(P<0.05);Ⅱb、Ⅱc之间无差异(P>0.05)。结论慢性低酶型乙型肝炎患者应用叶下珠初始治疗,在ALT升高达100U/L以上,适时加用或改用IFNα-2b治疗慢性乙型肝炎可获得满意的临床疗效。
Objective To explore the clinical effects of different prescriptions of Phyllanthus urinaria and interferon α-2b (IFNα-2b) in the treatment of chronic low-type hepatitis B. Methods: Fifty-two patients with low-type hepatitis B were treated with Phyllanthus tablets, and the ALT level was increased to 1000 U / L within 3 months. The patients were randomly divided into two groups: group Ⅱa, Ⅱ b group) were treated with IFNα-2b group (Ⅱc group), and those who were still low-enzyme group were treated as control group (group Ⅰ). All the patients in group Ⅰ and group Ⅱ were treated with different protocols under the same conditions Treatment for 6 months. Results The results of group Ⅱa, Ⅱb and Ⅱc were superior to group Ⅰ in ALT normalization, HBeAg negative conversion, anti-HBe positive conversion and HBVDNA negative conversion (P <0.05) ); There was no difference between Ⅱb and Ⅱc (P> 0.05). Conclusion Chronic low-enzyme hepatitis B patients with Phyllanthus starting treatment, elevated ALT up to 100U / L or more, timely or with IFNα-2b treatment of chronic hepatitis B can be obtained satisfactory clinical efficacy.