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本文报道达哪唑衍生物的合成,以期增加母体化合物的生物活性。采用3-酮物(Ia_c)为原料,在甲醇钠催化下与甲酸乙酯反应制得2-羟亚甲基化合物(Ⅱa_c),再与盐酸羟胺环合成
This article reports the synthesis of dazole derivatives, in order to increase the biological activity of the parent compound. The 3-keto compound (Ia_c) was used as the starting material to react with ethyl formate under the catalysis of sodium methoxide to obtain 2-hydroxymethylene (Ⅱa_c)