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目的评价精浆锌及血清生殖激素水平测定在不育症诊断及判定睾丸功能损害程度的意义。方法对200例男性不育症患者进行了精浆锌、血清生殖激素(FSH、LH、T、PRL)检测,并结合精液常规检查、睾丸容积测定以及睾丸病理活检进行分析。结果不育症患者精浆锌含量下降、血清生殖激素异常与睾丸间质细胞功能受损、生精上皮不同程度的破坏有明显的关系。结论精浆锌及血清生殖激素的检测,对判定男性不育症患者睾丸损害程度及鉴别睾丸原发性与梗阻性无精子症具有重要的作用。
Objective To evaluate the significance of determination of serum zinc and serum reproductive hormone levels in the diagnosis of infertility and the degree of testicular dysfunction. Methods Semen zinc, serum reproductive hormones (FSH, LH, T, PRL) were detected in 200 male infertility patients and analyzed by routine sperm test, testicular volume measurement and testicular biopsy. Results In infertility patients, the content of zinc in the seminal plasma was decreased. The abnormalities of serum reproductive hormones were related to the dysfunction of leydig cells and the destruction of the seminiferous epithelium. Conclusion The detection of seminal plasma zinc and serum reproductive hormones plays an important role in determining the degree of testicular damage in male infertility patients and in differentiating between primary and obstructive azoospermia in testis.