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检测30例肺癌患者及21例对照组肺组织致癌元素(砷、镉、镍)及抗癌或保护性元素(硒、锌)的含量。发现肺癌肺组织内砷、镉、镍3元素含量均不同程度地高于对照组,肺癌组内吸烟者3元素含量又高于不吸烟者。假设肺癌的发生不仅取决于致癌元素的绝对量,还取决于肺组织致癌元素/抗癌或保护性元素的综合效应,故以5元素综合效应比值。发现比值在反映患者吸烟与否、吸烟起始年龄及吸烟累积总量的危险性方面有一定规律性,从而以比较人肺生物监测的研究证明吸烟与肺癌的密切关系。
The contents of carcinogenic elements (arsenic, cadmium, nickel) and anti-cancer or protective elements (selenium, zinc) in lung tissues of 30 lung cancer patients and 21 control subjects were detected. The contents of arsenic, cadmium and nickel in the lung tissue of lung cancer were found to be higher than those in the control group. The content of 3 elements in the lung cancer group was higher than that in non-smokers. Assuming that the occurrence of lung cancer depends not only on the absolute amount of carcinogenic elements, but also on the combined effects of carcinogenic elements/anticancer or protective elements in lung tissues, it is based on a 5-element integrated effect ratio. The ratios were found to have some regularity in reflecting the risk of smoking or not, smoking initiation age, and total smoking accumulation. A comparison of lung biomonitoring studies has demonstrated the close relationship between smoking and lung cancer.