Innovative teaching methodologies in different parts of the world are being practiced since last 3 decades. The aim of this review is to report the transition from traditional to innovative self leaing process in Ziauddin Medical University, a new medical institute of Pakistan. Various problems encountered have been duly looked after by inducting faculty training programs and regular review sessions in which monitoring of the transition process was duly observed as well as further advancements were also planned. The University being a pioneer has attracted other institutions which have also planned to induct PBL in their curriculum.Vertical and horizontal integration has also inducted better understanding of subjects and fruitful advantages had been accomplished in subjects as pharmacology and pathology. In conclusion, the initial decision of the university to adapt innovative teaching methodologies along with following an integrated curriculum based on PBL and Community Oriented Medical Education system has now made ZMU a Novel institute amongst other medical institutes in the country.