目的 :探讨缺氧诱导因子 - 1α(Hypoxia induciblefactor 1α ,HIF 1α)在妊娠高血压综合征 (妊高征 )患者胎盘组织中蛋白的表达情况 .方法 :应用组织芯片技术 ,通过免疫组织化学方法分别检测妊高征患者和健康孕妇胎盘组织中HIF 1α蛋白的表达 .结果 :与正常胎盘组织相比 ,妊高征胎盘组织中HIF 1α的蛋白表达明显增高 (P <0 .0 5 ) .结论 :HIF 1α可能在蛋白水平上参与了妊高征发病及病理生理过程 . Objective: To investigate the expression of Hypoxia inducible factor 1α (HIF-1α) in placental tissue of patients with pregnancy induced hypertension (PIH) .Methods: Tissue microarray was used to detect the expression of HIF-1α To detect the expression of HIF-1α protein in placenta of patients with PIH and healthy pregnant women.Results: Compared with normal placenta, the protein expression of HIF-1α in placenta of PIH was significantly increased (P0.05) .Conclusion: HIF 1α may participate in the pathogenesis and pathophysiology of pregnancy-induced hypertension at the protein level.