【摘 要】
：
T The title compound VII, 2-fluoro-4-methyl-3-oxo-4-aza-5α-androst-1-ene-17β-car-boxylic acid methyl ester (C_(21)H_(30)FNO_3, M_r = 363.46), was prepared thr
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T The title compound VII, 2-fluoro-4-methyl-3-oxo-4-aza-5α-androst-1-ene-17β-car-boxylic acid methyl ester (C_(21)H_(30)FNO_3, M_r = 363.46), was prepared through a seven-step reaction from pregnenolone, and characterized by elemental and single-crystal X-ray diffraction analyses as well as IR, MS and ~1H-NMR spectra. It is of monoelinie system, space group P2_1/c with a = 6.3882(7), b = 9.9033(11), c = 15.4925(17) (A), β = 91.923(2)°, V= 979.57(19) (A)~3, Z= 2, D_c= 1.232 mg/m~3,μ = 0.088 mm~(-1), F(000)= 392, R = 0.0465, wR = 0.0989 and λ(MoKα) = 0.71073 (A). The structure indicates that the four cycles (A: C(1)-C(2)-C(3)-N(1)-C(5)-C(10), B: C(5)-C(6)-C(7)-C(8)-C(9)-C(10), C: C(8)-C(14)-C(13)-C(12)-C(11)-C(9), D: C(14)-C(15)-C(16)-C(17)-C(13)) are in chair- and trans-configurations. The results of crystal structure determination show that there exist weak intra-molecular hydrogen bonds, resulting in a two-dimensional supramoleeular frame-work of the title compound.
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