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目的比较地特胰岛素(Det)和中性精蛋白锌胰岛素(NPH)对口服降糖药控制不佳的T2DM患者血糖水平及其变异性的影响。方法 32例口服降糖药(OAD)控制不佳(HbA1c>7.5%)的T2DM患者随机分为两组,分别加用Det和NPH胰岛素治疗,治疗12周后,动态血糖监测系统(CGMS)进行连续72h的血糖监测。结果 (1)两组患者治疗12周后FBG、2hBG和HbA1c水平均较治疗前明显降低(P<0.01);而在治疗前后两组间FBG、2hBG和HbA1c均无统计学差异;(2)CGMS结果显示,两组间平均血糖水平差异无统计学意义(P>0.05),但Det组日内血糖最高值、日内血糖漂移最大幅度均明显低于NPH组(P<0.01)。结论 Det在改善T2DM患者血糖变异性方面优于NPH。
Objective To compare the effect of Det and Neprilysin (NPH) on blood glucose levels and their variability in T2DM patients with poorly controlled oral hypoglycemic agents. Methods Twenty-two T2DM patients with poor control of oral hypoglycemic agents (HbA1c> 7.5%) were randomly divided into two groups, treated with Det and NPH insulin respectively. After 12 weeks of treatment, dynamic glucose monitoring system (CGMS) Continuous 72h blood glucose monitoring. Results (1) The levels of FBG, 2hBG and HbA1c in two groups after treatment for 12 weeks were significantly lower than those before treatment (P <0.01), while there was no significant difference in FBG, 2hBG and HbA1c between the two groups before and after treatment (2) The results of CGMS showed that there was no significant difference in average blood glucose level between the two groups (P> 0.05). However, the highest intra-day blood glucose level and the highest daily intra-day glucose excursion in Det group were significantly lower than those in NPH group (P <0.01). Conclusion Det is superior to NPH in improving blood glucose variability in T2DM patients.