论文部分内容阅读
在实验性鸭乙型肝炎病毒(DHBV)感染的模型中,研究了用新城鸡瘟病毒(NDV)及双链RNA制剂(dsRNA)诱生白细胞及脾细胞的干扰素(IFN)反应。结果发现在樱桃谷鸭中,DHBV-DNA持续阳性鸭中,白细胞对dsRNA诱生IFN反应低下。在北京鸭DHBV-DNA持续阳性鸭中未能发现与对照组间的显著差别。在去党氏囊后感染DHBV的樱桃谷鸭中,发现其脾细胞及白细胞产生IFN效价均较未去法氏囊组为低,但仅脾细胞产生IFN低下有统计学显著意义。提出了用各种诱生剂检测IFN反应的重要性及测定肝内局部产生IFN的价值。
In a model of experimental duck hepatitis B virus (DHBV) infection, the interferon (IFN) responses of leukocytes and splenocytes were induced with NDV and dsRNA. The results showed that cherry Valley ducks, DHBV-DNA persistent ducks, white blood cells induced by dsRNA low IFN response. No significant difference from the control group was found in Duck DHBV-DNA persistence ducks. In the Cherry Valley ducks infected with DHBV after going to the Stomach capsule, the IFN titers of spleen cells and leukocytes were found to be lower than those of the non-Bursal disease group, but only the spleen cells with low IFN production were statistically significant. The importance of detecting IFN responses with various inducers and the value of determining the local production of IFN in the liver have been proposed.