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目的 :探讨萎胃散治疗慢性萎缩性胃炎 (CAG)的疗效及其机制。方法 :用主动免疫、乙醇、去氧胆酸钠及热糊灌胃同时进行的综合方法 ,制成大鼠 CAG模型。造模后治疗组以萎胃散大、小剂量治疗 6 0 d,观察指标以胃粘模固有腺体萎缩程度为依据。对照组仅予生理盐水灌胃。结果 :治疗组的 CAG病变数量明显减少 ,病理检查可见腺体恢复正常。治疗组与模型组 (不给药治疗 )比较有显著性差异 (P <0 .0 5 )。结论 :萎胃散的应用可使胃粘膜固有腺体增多 ,有良好的治疗 CAG的作用。
Objective: To explore the efficacy and mechanism of Weiwei Powder in the treatment of chronic atrophic gastritis (CAG). Methods : A rat CAG model was established by a combination of active immunization, ethanol, sodium deoxycholate and hot paste. After treatment, the treatment group was treated with Weiwei bulk and small doses for 60 d. The observation index was based on the degree of glandular atrophy of gastric mucosa. The control group only received gavage of normal saline. RESULTS: The number of CAG lesions in the treatment group was significantly reduced. The pathological examination showed that the glands returned to normal. There was a significant difference between the treatment group and the model group (without treatment) (P < 0.05). Conclusion : The use of Weiwei Powder can increase the number of glands in the gastric mucosa and it has a good effect on the treatment of CAG.