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目的探讨慢性肾功能不全患者血液胆汁酸浓度变化的病理机制。方法分析观察组和对照组血液胆固醇、胆汁酸、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)浓度变化情况并进行统计学分析。结果观察组各测定指标显著高于对照组。结论细胞炎性分子通过抑制胆汁酸的合成和抑制胆盐转运蛋白基因表达从而抑制肝细胞对血液中胆汁酸的重吸收和肝细胞对胆汁酸的排泌,使胆汁酸的肠肝循环减弱而血液胆汁酸浓度增高。
Objective To investigate the pathological mechanism of blood bile acid concentration in patients with chronic renal failure. Methods The changes of blood cholesterol, bile acid, tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) concentrations in the observation group and the control group were analyzed and statistically analyzed. Results The observation group was significantly higher than the control group. Conclusions The cytokines can inhibit the reabsorption of bile acid in the blood and the excretion of bile acid by hepatocytes by inhibiting the synthesis of bile acids and inhibiting the expression of bile salt transporter genes, Blood bile acid concentration increased.