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非典型性脑膜瘤是WHO II级脑膜瘤,其性质介于良性脑膜瘤和恶性脑膜瘤之间。近年来关于非典型性脑膜瘤的研究有了较大的进展。目前关于非典型性脑膜瘤发现常染色体22q,1p、6q等的缺失以及1q、9q、12q、等染色体的扩增,核增殖标记物Ki67(MIB-1)、细胞凋亡相关蛋白、生长因子等在非典型性脑膜瘤的发生及复发中有重要作用。临床影像学表现有助于做出诊断,而明确诊断主要依靠组织病理学检查。手术切除是主要的治疗手段,其他的治疗措施还包括立体定向放射治疗、外部照射放射治疗、低分次立体定向放射疗法等。
Atypical meningioma is a WHO grade II meningioma, the nature of which is between benign meningioma and malignant meningioma. In recent years, research on atypical meningioma has made great progress. At present, atypical meningiomas have found the deletion of autosomal chromosomes such as 22q, 1p and 6q, and the amplification of chromosomes such as 1q, 9q and 12q, nuclear proliferation marker Ki67 (MIB-1), apoptosis related protein, growth factor Etc. plays an important role in the occurrence and recurrence of atypical meningioma. Clinical imaging findings help to make a diagnosis, and a clear diagnosis depends mainly on histopathological examination. Surgical resection is the main treatment, other treatments include stereotactic radiotherapy, external radiation therapy, low-level stereotactic radiotherapy and so on.