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目的 了解全民食盐加碘防治方案在非碘缺乏病（ＩＤＤ）地区的实施效果及其对儿童甲状腺功能的影响。方法以合肥市７～１４岁儿童为观察对象，分别在全民食盐加碘前和加碘后１年，测定其甲状腺吸１３１碘率的改变，并结合其他相关指标作分析。结果加碘盐能明显抑制非病区儿童的甲状腺吸１３１碘率，提高尿碘水平，但加碘后甲状腺肿大率的明显升高、过氯酸钾排泌的增加、血清甲状腺自身抗体和ＦＴ３水平的升高等，提示甲状腺吸１３１碘率受抑制的机制可能较为复杂。结论实施全民食盐加碘方案纠正儿童碘营养不足的效果肯定，但对非ＩＤＤ病区儿童甲状腺有高碘损害的忧虑，值得进一步探讨。
Objective To understand the implementation of universal salt iodization prevention and control programs in non-iodine deficiency disease (IDD) areas and their effects on thyroid function in children. Methods Children aged 7-14 years old in Hefei city were observed. Changes of thyroid uptake of iodine 131 before and after iodization of common people were measured respectively, and other related indexes were analyzed. The results of iodized salt can significantly inhibit non-ward children thyroid uptake of 131 iodine rate and increase urinary iodine levels, but after iodine increased goiter rate was significantly increased potassium perchlorate excretion, serum thyroid autoantibodies and FT3 levels , Suggesting that the mechanism by which thyroid uptake of 131 iodine may be suppressed may be complicated. Conclusion The implementation of universal salt iodization program to correct children iodine deficiency insufficiency effect, but non IDD ward children with thyroid iodine damage concerns worth further study.