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丙型肝炎病毒(HCV)是人类首次应用分子克隆手段在未获得病毒颗粒和未测到病毒抗原的情况下发现的病毒,并进一步应用克隆和重组表达手段对HCV的基因结构、功能进行了探索且获得了较全面的认识,但有关该病毒的复制、病理作用、抗病毒药物筛选、疫苗的研究方面进步甚微,这主要是由于缺乏理想的HCV细胞模型和廉价易得的动物模型造成的。因此有关HCV细胞及动物模型的研究成为其他相关研究进步的关键。近10年来众多研究者对此方面进行了研究,本文即对此作一简要综述。
Hepatitis C virus (HCV) is the first human being to use molecular cloning to find out the virus without virion and virus antigen, and to further explore the gene structure and function of HCV by cloning and recombinant expression And obtained a more comprehensive understanding, but the virus replication, pathological effects, screening of antiviral drugs, vaccines made little progress, mainly due to the lack of the ideal HCV cell model and cheap and easy to get animal model caused . Therefore, the research on HCV cells and animal models has become the key to other related research progress. In the past 10 years, many researchers have studied this aspect, this article is a brief overview of this.