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目的探讨蚕蛹油对高脂血症大鼠的调血脂作用及机制。方法高脂饮食复制大鼠高脂血症模型,以蚕蛹油ig给药6周,每两周检测大鼠血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)、卵磷脂胆固醇转移酶(LCAT)、脂蛋白脂酶(LPL)、肝脂酶(HL)水平,第6周处死后,称量肝质量,并检测肝中LPL、HL水平。结果蚕蛹油各组的血脂(TG、TC)、脂蛋白(HDL-C、LDL-C)、载脂蛋白(ApoAI、ApoB)、LCAT及总酯酶水平与模型组各指标相比均具有显著差异(P<0.05),并具有剂量依赖性,且相应酶的变化早于血脂和脂蛋白的变化。结论蚕蛹油可以通过激活载脂蛋白和脂代谢相关酶,调整血清中血脂和脂蛋白水平,从而达到治疗高脂血症的目的。
Objective To investigate the effects of silkworm pupa oil on hyperlipemia in hyperlipidemic rats and its mechanism. Methods Hyperlipidemia was induced by high-fat diet in rats and the rats were treated with chrysalis oil ig for 6 weeks every two weeks. The levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL) C, LDL-C, ApoAI, ApoB, LCAT, LPL, Enzyme (HL) levels were measured after 6 weeks of sacrifice, and liver LPL and HL levels were measured. Results Serum lipids (TG, TC), lipoprotein (HDL-C, LDL-C), apolipoprotein (ApoB), LCAT and total esterase levels of silkworm pupae group were significantly higher than those of model group (P <0.05), and in a dose-dependent manner. The change of corresponding enzymes was earlier than that of lipids and lipoproteins. Conclusions Silkworm pupa oil can regulate serum lipids and lipoproteins by activating apolipoprotein and lipase-related enzymes, so as to achieve the goal of treating hyperlipidemia.