奥曲肽又名善保定,是一种人工合成的长效型生长激素释放抑制素,临床上主要用于转移性类癌,胃肠道及胰腺的内分泌肿瘤,急性胰腺炎,上消化道出血等多种疾病。而其因价格昂贵,临床应用仍不普及。我院在食道静脉曲张破裂出血中多次应用,本文就此进行综述。1.药理作用 现经临床研究及动物实验表明,奥曲肽为一人工合成的生长抑素,既保留了天然生长抑素的全部生物活性,又大大延长了其生物半衰期,且其生物活性比天 Octreotide, also known as good Baoding, is a synthetic long-acting somatostatin, clinically used mainly for metastatic carcinoid, gastrointestinal and pancreatic endocrine tumors, acute pancreatitis, upper gastrointestinal bleeding and more Diseases. Because of its expensive, clinical application is still not popular. Our hospital repeatedly used in esophageal variceal bleeding, this article is reviewed. 1. Pharmacological effects Now clinical studies and animal experiments show that octreotide is a synthetic somatostatin, which retains all the biological activity of natural somatostatin, but also greatly extended its biological half-life, and its biological activity than the day