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目前发现有多个miRNA和miRNA簇在人类乳腺癌干细胞中发挥多种调节作用,其中,microRNA还参与多种信号通路的调节,在维护和调节乳腺癌干细胞与正常乳腺干/祖细胞增殖分化中发挥重要的作用。这些信号通路和基因包括自我更新因子Bmi-1、凋亡信号通路、Wnt信号通路、Notch信号通路和EMT等。下面从这几个方面入手,对乳腺癌干细胞中miRNAs
Several miRNA and miRNA clusters have been found to play various regulatory roles in human breast cancer stem cells. Among them, microRNAs are also involved in the regulation of multiple signaling pathways in the maintenance and regulation of proliferation and differentiation of breast cancer stem cells and normal mammary stem / progenitor cells Play an important role. These signal pathways and genes include the self-renewing factor Bmi-1, apoptosis signaling pathway, Wnt signaling pathway, Notch signaling pathway and EMT. The following from these aspects, breast cancer stem cells miRNAs