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目的：探究急性脑桥梗死后并发不宁腿综合征患者的临床特点、梗死灶累及周围组织和可能病理机制。方法总结本研究急性脑桥梗死并发不宁腿综合征3例男性患者的临床和影像学资料，并与文献报道8例患者的临床资料合并进行分析。结果患者的中位年龄为58岁(53，62)，男性患者比例为63.6%(7/11例)；临床多表现为偏瘫伴构音障碍；影像学分析提示病灶多位于脑桥腹内侧面，病灶纵深比值为78%(62%,82%)，责任血管为脑桥旁正中支。脑桥核，而非网状结构为频率最高的累及结构。结论急性脑桥梗死与不宁腿综合征之间存在因果关系，可能与梗死灶累及脑桥核有关。“,”Aim To explore the possible structure responsible for restless legs syndrome after acute pons infarction. Methods Three consecutive cases admitted in our hospital between Dec 2012 and Jan 2014 in addition to eight cases from literature were collected. Clinical presentations were analyzed. Results Elevencases (median age of 58 and 63.6%male) were included. The most common clinical presentations were hemiplegia and dysarthria. Magnetic resonance imaging revealed that the ventral-median lesion of pons supplied by the paramedian branches of basilar artery, with a longitude-depth ratio of 78%(62%, 82%), was the most often involved. Pontine nuclei rather than reticular formation was the site most frequently affected. Conclusion Pontine nuclei might be one of the anatomic lesions of restless legs syndrome.