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目的:探讨血尿酸与下肢动脉钙化的相关性。方法:选择2010年1月至2015年12月收治于中山大学孙逸仙纪念医院并行下肢CT检查的病例,共164例。收集患者的临床资料以及血清生化指标。通过CT扫描和Agatston评分系统评估下肢动脉钙化,分析血尿酸与下肢动脉钙化的相关性。结果:与正常尿酸组比较,高尿酸血症组血球蛋白升高(P<0.05);正常尿酸组与高尿酸组的下肢动脉钙化积分无统计学差异(P>0.05)。尿酸与下肢动脉钙化积分无显著相关性(r=0.026,P>0.05),校正球蛋白因素后,尿酸与下肢动脉钙化积分仍无显著相关性(P均>0.05)。高尿酸血症组与正常尿酸组无/轻、中、重度钙化的发生率无统计学差异(P>0.05)。结论:尿酸与下肢动脉钙化可能不存在直接相关性。
Objective: To investigate the correlation between serum uric acid and artery calcification in lower extremities. Methods: A total of 164 cases of lower extremity CT examination underwent Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2010 to December 2015 were selected. Collect the clinical data of patients and serum biochemical indicators. Lower extremity arterial calcification was assessed by CT scan and Agatston scoring system, and the correlation between serum uric acid and lower extremity arterial calcification was analyzed. Results: Compared with normal uric acid group, hyperuricemia group had elevated blood globulin (P <0.05). There was no significant difference in arterial calcification scores between normal uric acid group and high uric acid group (P> 0.05). There was no significant correlation between uric acid and arterial calcification score (r = 0.026, P> 0.05). There was no significant correlation between uric acid and arterial calcification score (all P> 0.05) after correction for globulin factor. The incidence of no / mild, moderate and severe calcification in hyperuricemia group and normal uric acid group had no statistical difference (P> 0.05). Conclusion: There may not be a direct correlation between uric acid and calcification of lower extremity arteries.