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过敏原表位是过敏原直接参与免疫反应的物质基础,也是导致过敏反应的“元凶”。牛乳β-乳球蛋白是lipocalin家族的代表和常用模式蛋白,它的表位信息比较完整,拥有7个人血清IgE和6个IgG的线性表位、3个IgE结合的构象性表位以及7个T细胞表位。另外,它的动物源血清IgE、IgG和T细胞表位也在不断被发现。牛乳β-乳球蛋白的表位信息为基于表位的应用提供了重要的支撑,它们的应用主要涉及到预测食物过敏原的致敏性,食物过敏的交叉反应,食物过敏的诊断,食物过敏的免疫治疗以及食物过敏原的检测等5个方面。
Allergen epitope is the material basis for the allergen directly involved in the immune response, but also lead to allergic reactions “culprit.” Milk β-lactoglobulin is a representative of the lipocalin family and a common pattern of protein, its more complete epitope information, with seven human serum IgE and 6 linear epitopes of IgG, conformational epitopes and three IgE binding 7 T cell epitope. In addition, its animal serum IgE, IgG and T cell epitopes are constantly being found. The epitope information of bovine milk β-lactoglobulin provides important support for the application based on epitopes. Their application mainly involves the prediction of the sensitization of food allergens, the cross-reaction of food allergy, the diagnosis of food allergy, the food allergy Immunotherapy and food allergen testing five aspects.