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目的 探讨慢性阻塞性肺疾病(COPD)患者静态肺功能和弥散功能对运动能力的影响。方法 选择2002-04~12中国医科大学第一临床学院稳定期COPD患者26例,进行症状限制性最大运动负荷观察(SLME)。运动前测量患者静态肺功能[1秒钟用力呼气容积(FEV1 )、努力肺活量(FVC)、肺活量(VC) ]和弥散功能[肺一氧化碳弥散量(DLCO) ];运动时代谢车测量患者呼吸困难指数(DI)和千克体重耗氧量(V·2 /kg)的变化;BorgScales(BS)被用于判定患者运动时呼吸困难的程度。结果 V·O2max/kg与诸变量的多元回归分析结果:V·O2max/kg=15. 37×DLCO% +28 .11×FEV1 /VC-7. 56×G。结论 静态肺功能和弥散功能障碍是导致COPD患者运动能力下降的重要因素。
Objective To investigate the effects of static pulmonary function and diffusibility on exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty-six patients with stable COPD at the First Clinical College of China Medical University from 2002-04 to 12 were selected for maximum symptom-limited exercise load (SLME). Pre-exercise measurements were performed on patients with static lung function (FEV1, FVC, VC) and diffuse function (DLCO); during exercise time, the car was used to measure the patient’s breathing Changes in difficulty index (DI) and kg body weight oxygen consumption (V · 2 / kg); BorgScales (BS) was used to determine the extent of dyspnea when the patient exercised. Results Multiple regression analysis of V · O2max / kg with variables showed that V · O2max / kg = 15.37 × DLCO% +28 .11 × FEV1 / VC-7.56 × G. Conclusions Static pulmonary function and diffuse dysfunction are important factors leading to decreased exercise capacity in COPD patients.