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目的探讨老年原发性高血压患者与高胰岛素血症、胰岛素抵抗(INSR)、高血脂和肥胖相关因素进行分析。方法对无糖尿病病史的老年原发性高血压患者100例,老年对照组50例的空腹血糖及餐后2 h血糖(FBG)、胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、体重指数(BMI)、胰岛素敏感指数(ISI)和脂肪分布指数(WHR)进行对照分析对比。结果高血压组的BMI,WHR,FBG,FINS,TG水平高于对照组,ISI低于对照组。经多元分析,ISI与TG,BMI,WHR呈负相关,与HDL呈正相关。结论老年高血压患者多伴有糖代谢和脂蛋白代谢异常,胰岛素抵抗所产生的高胰岛素血症为其基本的代谢异常,这是造成高血压病并发冠心病发生的重要原因之一。
Objective To investigate the factors associated with hyperinsulinemia, insulin resistance (INSR), hyperlipidemia and obesity in elderly patients with essential hypertension. Methods Fasting plasma glucose (FBG), fasting blood glucose (FBG), insulin (FINS), triglyceride (TG) and total cholesterol (TC) were measured in 100 elderly patients with senile hypertension without diabetes mellitus and 50 elderly controls. ), HDL, BMI, ISI and WHR were compared. Results The levels of BMI, WHR, FBG, FINS and TG in hypertension group were higher than those in control group, and the ISI was lower than that in control group. After multivariate analysis, ISI was negatively correlated with TG, BMI and WHR, and positively correlated with HDL. Conclusions The elderly patients with hypertension are often accompanied by abnormal glucose metabolism and lipoprotein metabolism. Hyperinsulinemia caused by insulin resistance is the basic metabolic abnormality, which is one of the important causes of hypertension complicated with coronary heart disease.