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本文研究黄磷与CCl_4引起亚急性肝损害时,肝脏发生脂质过氧化的情况、部位及其与肝损害之间的关系。黄磷与CCl_4对大鼠亚急性中毒时,肝MDA 含量显著升高,Schiff 碱荧光强度明显增强;肝线粒体与微粒体MDA含量显著升高,且各自标志酶SDHase 活性与G-6-Pase 活性均显著降低;肝损害指标:肝TG 含量升高对两种毒物均敏感;而肝GSH 含量降低与血清SGPT 酶活性升高对两种毒物的敏感性有一定的差异。
This study was to investigate the relationship between lipid peroxidation in liver and its location and liver damage in subacute liver damage caused by yellow phosphorus and CCl_4. In the sub-acute toxicity of phosphorus and CCl_4, the content of MDA in liver increased significantly and the fluorescence intensity of Schiff base increased obviously. The content of MDA in liver mitochondria and microsome increased significantly, and the activities of SDHase and G-6-Pase Were significantly lower; liver damage indicators: elevated liver TG were sensitive to both poisons; and decreased liver GSH content and serum SGPT enzyme activity increased sensitivity of the two poisons have some differences.