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以磁性四氧化三铁(Fe_3O_4)纳米粒子和可降解聚合物聚乳酸-羟基乙酸共聚物为原料,采用乳化-溶剂挥发法制备获得磁性聚合物微球。通过傅里叶红外光谱、热失重曲线、透射电子显微镜、振动样品磁强计对所制备的磁性聚合物微球的各项性能进行表征,并利用高频磁感应设备测定磁性聚合物微球的磁感应加热性能。结果表明,所制备的两种磁性聚合物微球中Fe_3O_4纳米粒子的含量分别为10.1%和18.8%,其比饱和磁化强度分别为2.3 emu/g和6.8 emu/g;在高频磁场作用下,8 min内升温分别可达到9℃和16.5℃,完全满足肿瘤磁热疗的升温需求,在肿瘤磁热疗及热化疗结合治疗中有着很好的应用潜力。
Magnetic polymer microspheres were prepared by emulsion-solvent evaporation method using magnetic Fe3O4 nanoparticles and biodegradable polymer poly (DL-lactide-co-glycolide) as raw materials. The properties of the prepared magnetic polymer microspheres were characterized by Fourier transform infrared spectroscopy, thermogravimetry, transmission electron microscopy and vibrating sample magnetometer. The magnetic induction of magnetic polymer microspheres was measured by high frequency magnetic induction equipment Heating performance. The results showed that the content of Fe 3 O 4 nanoparticles in the two kinds of magnetic polymer microspheres were 10.1% and 18.8%, respectively, and their specific saturation magnetrons were 2.3 emu / g and 6.8 emu / g respectively. Under the action of high frequency magnetic field , 8 min heating up to 9 ℃ and 16.5 ℃ respectively, fully meet the heating needs of tumor thermotherapy, has a good potential in the combination therapy of tumor thermotherapy and thermotherapy.