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The benefits of estrogen in cardiovascular system include a reduction in low-density lipoprotein cholesterol (LDL-C),decrease in LDL oxidation,and enhancement of vascular function [1].Estrogen replacement therapy,however,has been linked to an increased risk of tissue-specific side effects including breast cancer and uterine cancer [2].These issues have led to the development of hormone replacement therapy (HRT) which combines estrogen and progestin.