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1980年David首先报告用大剂量已酸孕酮(250mg/次)肌肉注射治疗2例输尿管结石,皆于24小时内排出结石.吴友椿等从1981年10月起用黄体酮(100mg,肌注,每日一次,三天为一疗程)治疗30例输尿管结石,总排石率为83.3%.我们用观察记录在体动物输尿管蠕动生物电变化的方法,测试肌注大剂量黄体酮对在体大鼠输尿管的影响,结果提示黄体酮能抑制输尿管的活动,降低其肌张力.现报告如下.
In 1980 David first reported the use of large doses of acid progesterone (250mg / time) intramuscular injection of ureteral stones in two cases, were discharged within 24 hours of stones. Wu Youchun from October 1981 with progesterone (100mg, intramuscular injection Once a day, three days for a course of treatment) treatment of 30 cases of ureteral stones, the total row of stone was 83.3% .We observed the recording in vivo animal ureter biopotentiation method to test high-dose intramuscular injection of progesterone in rats Ureteral effects, the results suggest that progesterone can inhibit the activity of the ureter and reduce its muscle tone .Reports are as follows.