纳洛酮(Naloxone)是阿片受体阻断剂,在临床上的主要用途是逆转吗啡及其它麻醉药品应用后出现的呼吸衰竭。近来,生理学家通过对应激状态下的内啡呔研究,为临床开辟了一条新的治疗途径,即通过纳洛酮来抢救休克和呼吸衰竭。 内啡呔与应澈 在某些实验性高血压、休克、及其它应激状态的实验研究中,动物体内有内源性阿片样物质的释放与阿片受体的激活。并且发现,这种内源性阿片样物质即β—内啡呔(β—endorphin)。Teffcoate认为,内源性阿片样物质是 Naloxone, an opioid receptor blocker, has been clinically used primarily to reverse respiratory failure after morphine and other narcotic applications. Recently, physiologists have opened up a new therapeutic approach to clinical treatment of endorphins under stressful conditions, namely, the rescue of shock and respiratory failure by naloxone. Endorphins and Ying Che In some experimental studies of hypertension, shock, and other stress states, animals have endogenous opioid release and opioid receptor activation. And it has been found that this endogenous opioid is β-endorphin. Teffcoate believes that endogenous opioids are