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目的探讨右旋美托咪啶用于预防小儿七氟醚麻醉术后急性躁动的有效剂量。方法选择2011年1月—2012年3月行腹股沟斜疝修补手术的患儿69例,随机分为R1、R2、R3三组各23例,手术开始前5 min,R1组静脉注射生理盐水2 ml,R2组和R3组分别静脉注射右旋美托咪啶0.15μg/kg、0.30μg/kg。记录患者血压、心率、呼吸次数及在麻醉结束后睁眼的时间。结果麻醉结束后睁眼的时间R1组为(8.5±4.0)min,R2组为(9.2±5.0)min,R3组为(10.8±4.0)min,R1组与R3组比较差异有统计学意义(P<0.05)。急性躁动发生率R1组为39.13%,R3组为8.70%,两组比较差异有统计学意义(P<0.05)。结论右旋美托咪啶可有效预防小儿七氟醚麻醉术后急性躁动,0.30μg/kg的剂量有效且安全。
Objective To study the effective dose of dexmedetomidine for preventing acute agitation after pediatric sevoflurane anesthesia. Methods Sixty-nine children undergoing inguinal hernia repair between January 2011 and March 2012 were randomly divided into three groups (R1, R2 and R3), each of which was treated with intravenous injection of saline 2 ml, and the R2 and R3 groups received intravenous dexmedetomidine 0.15μg / kg and 0.30μg / kg, respectively. Record patient’s blood pressure, heart rate, number of breaths and time to open eyes after anesthesia. Results The time of open eyes after anesthesia was (8.5 ± 4.0) min in R1 group, (9.2 ± 5.0) min in R2 group, and (10.8 ± 4.0) min in R3 group. There was significant difference between R1 group and R3 group P <0.05). The incidence of acute agitation was 39.13% in group R1 and 8.70% in group R3, with significant difference between the two groups (P <0.05). Conclusion Dexmedetomidine can effectively prevent acute agitation of children after sevoflurane anesthesia, and the dose of 0.30μg / kg is effective and safe.