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我们应用苯那普利治疗42例非胰岛素依赖型糖尿病(NIDDM)并进行了疗效观察。现报告如下。 资料与方法 42例NIDDM均为临床蛋白尿期,其中男27例,女15例,平均58.5岁。糖尿病病程平均5.6年,糖尿病肾病病程平均2.3年,其中3例病程短于一年而尿蛋白排泄大于3.5g/24h,行肾活检发现典型Kimmelstrel-Wilsom结节,排除其他原因所致蛋白尿。24小时尿蛋白定量平均2.7克,伴高血压者收缩压>18.7kPak(140mmHg),或舒张压>12.7kPak(95mmHg)23例,平均动脉压(MAP)17.1kPa(128.5mmHg),MAP=收缩压+舒张压)÷2。正常血压19例,MAP14kPa(105mmHg),血浆葡萄糖平均7.3mmol/L。试验者在上午8～11时测MAP,~(99)锝DTAP肾动态显像测定肾小球滤过率(GFR),正常值为90～110ml·min~(-1)/1.73m~2试验前及期间所有患者给标准糖尿病饮食及口服降糖药
We applied benazepril to treat 42 non-insulin dependent diabetes mellitus (NIDDM) and observed the efficacy. The report is as follows. Materials and Methods 42 cases of NIDDM are clinical proteinuria, including 27 males and 15 females, average 58.5 years old. The average duration of diabetes was 5.6 years. The duration of diabetic nephropathy was 2.3 years. Three of them had a disease duration of less than one year and urinary protein excretion of more than 3.5g / 24h. A typical Kimmelstrel-Wilsom nodule was found on renal biopsy, and other causes of proteinuria were excluded. 24-hour urinary protein was measured in a mean of 2.7 grams with systolic blood pressure> 18.7 kPak (140 mmHg) or diastolic blood pressure> 12.7 kPak (95 mmHg) in 23 cases with mean arterial pressure (MAP) of 17.1 kPa (128.5 mmHg) Pressure + diastolic pressure) ÷ 2. Normal blood pressure in 19 cases, MAP14kPa (105mmHg), plasma glucose average 7.3mmol / L. The test subjects measured MAP and ~ (99) technetium-DTAP renal dynamic imaging to measure GFR at 8-11 am, with a normal range of 90-110 ml · min -1 (-1.73 m 2) All patients before the test and during the period to the standard diabetic diet and oral hypoglycemic agents