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作者对24例急性大脑中动脉皮质梗死的澳大利亚病人进行了研究,15例接受链激酶治疗,9例使用安慰剂。两组病人在治疗前后行SPECT,3个月后复查用标准的容量分析技术测量梗死区的低灌注量。神经损害及功能预后用加拿大神经病学评分标准及Barthel标准进行评估。结果两组病人早期血流再灌注无显著性差异,但是链激酶可增加卒中后较大量的非营养性再灌注,这一过度灌注与功能恢复不良有关。
The authors studied 24 Australian patients with acute cerebral infarction of the middle cerebral artery, 15 received streptokinase, and 9 received placebo. Two groups of patients underwent SPECT before and after treatment and were reviewed after 3 months. Low volume perfusion in the infarct zone was measured using standard volumetric techniques. Nerve damage and functional outcome were assessed using the Canadian Neurological Score and Barthel criteria. Results There was no significant difference in early blood flow reperfusion between the two groups, but streptokinase increased the number of non-nutritive reperfusion after stroke. This over-infusion was associated with poor recovery of function.