论文部分内容阅读
采用化学分析方法观察单纯皮肤型和肾型过敏性紫癜血清脂质过氧化物（ＬＰＯ），全血超氧化物歧化酶（ＳＯＤ），全血谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）和全血谷胱甘肽（ＧＳＨ）的变化。结果：单纯皮肤型过敏性紫癜急性期患儿血清ＬＰＯ高于对照组（Ｐ＜０．０５），恢复期与对照组无显著差异（Ｐ＞０．０５）。ＳＯＤ、ＧＳＨ－ｐｘ、ＧＳＨ与对照组无显著差异（Ｐ值均＞０．０５）。肾型过敏性紫癜急性期患儿血清ＬＰＯ高于对照组，ＳＯＤ、ＧＳＨ－ｐｘ、ＧＳＨ低于对照组（Ｐ值均＜０．０１），恢复期ＬＰＯ、ＳＯＤ虽有恢复，但与对照组仍有差异（Ｐ值均＜０．０５），ＧＳＨ－ｐｘ、ＧＳＨ与对照组无差异（Ｐ值均＞０．０５）。提示过敏性紫癜患儿脂质过氧化作用增强，肾型重于单纯皮肤型，且抗氧化机能下降。ＬＰＯ、ＳＯＤ、ＧＳＨ－ｐｘ、ＧＳＨ可作为判断本病病情变化的指标，并为应用抗氧化剂治疗提供理论和实验依据。
The levels of serum lipid peroxidation (LPO), whole blood superoxide dismutase (SOD), whole blood glutathione peroxidase (GSH-px) And whole blood glutathione (GSH) changes. Results: Serum LPO in children with acute cutaneous anaphylactoid purpura was higher than that in control group (P <0.05), and there was no significant difference between recovery group and control group (P> 0.05). SOD, GSH-px, GSH and the control group no significant difference (P values> 0.05). Serum LPO in children with acute renal nephritis was higher than that in the control group, and the levels of SOD, GSH-px and GSH were lower than those in the control group (all P <0.01). LPO and SOD recovered at recovery, (P <0.05). There was no difference between GSH-px, GSH and control group (P> 0.05). Prompted hyperalgesia in children with Henoch-Schonlein purpura enhancement, kidney type heavier than the simple skin type, and anti-oxidant function decreased. LPO, SOD, GSH-px, GSH can be used as indicators to judge the changes of the disease, and provide theoretical and experimental basis for the application of antioxidants.