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目的:检测少精子症和/或弱精子症患者空腹血浆同型半胱氨酸(homocysteine,Hcy)水平,并探讨其临床意义。方法:86例少精子症和/或弱精子症患者分为3组:少精子症组(n=21),弱精子症组(n=32),少弱精子症组(n=33);对照组(n=19)为精子密度及活力正常的健康男性精液。分别进行精液常规分析和空腹血浆同型半胱氨酸水平测定。结果:3组患者血浆Hcy水平均显著高于健康对照组(P<0.05),3组患者间血浆Hcy水平无显著性差异(P>0.05)。血浆中Hcy水平与3组患者的a级精子百分率、(a+b)级精子百分率及密度之间均呈负相关(r=-0.303、-0.339、-0.433,P<0.05)。结论:人血浆Hcy水平升高可能会直接或间接地影响精子发生,与少和/或弱精子症密切相关。
Objective: To detect the level of fasting plasma homocysteine (Hcy) in patients with oligospermia and / or asthenospermia and to explore its clinical significance. Methods: Eighty - six patients with oligospermia and / or asthenospermia were divided into three groups: oligozoospermia group (n = 21), asthenospermia group (n = 32), oligozoospermia group (n = 33) The control group (n = 19) was healthy male sperm with normal sperm density and vitality. Semen routine analysis and fasting plasma homocysteine levels were measured. Results: Plasma homocysteine levels were significantly higher in the three groups than in the healthy controls (P <0.05). There was no significant difference in plasma homocysteine levels between the three groups (P> 0.05). Plasma Hcy levels were negatively correlated with a-grade sperm percentage, (a + b) sperm percentage and density in the three groups (r = -0.303, -0.339, -0.433, P <0.05). Conclusion: Elevated plasma levels of Hcy may directly or indirectly affect spermatogenesis, which is closely related to less and / or weaker spermatozoa.