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应用低硒和补硒合成饲料喂养５周龄ＢＡＬＢ／Ｃ雄性小鼠５周后，经腹腔接种柯萨奇Ｂ３ｍ病毒（ＣＶＢ３ｍ）１０２ＴＣＩＤ５０，１ｍｌ对照组腹腔注射ＰＲＭ１６４０，光镜下低硒病毒组（Ｉ组），补硒病毒组（Ⅱ组）病变检出率分别为 ７５％和 ３５％，经 Ｘ２检验 Ⅰ组显著高于Ⅱ组（ Ｐ＜ ０． ０５）。且病变部位不同，低硒病毒 Ⅰ组病变主要位于左心室中层，大体标本未见心肌外膜白斑。Ⅱ组见于心外膜及心外膜下心肌，大体标本可见心外膜白斑。补硒对照组（Ⅲ）无病变。电镜结果（ Ｉ）组超微结构病变明显重于 Ⅱ组。提示硒缺乏可加重病毒感染引起的心肌病变。
Five weeks old BALB / C male mice were fed with low selenium and selenium supplemented synthetic diet for 5 weeks. The mice were inoculated intraperitoneally with CVB3m 102TCID50 and 1 ml control group. PRM1640 was injected intraperitoneally, I group), selenium-containing virus group (Ⅱ group) were 75% and 35%, respectively, which was significantly higher in group Ⅰ than in group Ⅱ by X2 test (P <0.05). And the lesion site is different, low selenium virus group Ⅰ lesions mainly located in the middle of the left ventricle, the general specimen no myocardial epicardial leukoplakia. Ⅱ group found in the epicardium and epicardial myocardium, epicardium can be seen in the general specimen white. Selenium control group (Ⅲ) no lesions. Electron microscopy results (I) group of ultrastructural lesions was significantly heavier than in group II. Tip selenium deficiency may aggravate the viral infection caused by myocardial lesions.