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目的研究临床癌性疼痛患者采用芬太尼透皮贴剂治疗的有效性。方法 67例恶性肿瘤患者作为本次研究对象,所有患者均采用芬太尼透皮贴治疗,对于初诊的患者初始剂量为25μg/h,72 h更换1次,并根据患者既往的吗啡应用情况随时调整药物剂量,直到达到理想的止痛效果,持续治疗15 d后分析其临床疗效,并比较治疗前后疼痛症状评分,并观察药物不良反应发生情况。结果治疗后,本组患者39例显效,24例有效,4例无效,疼痛症状缓解总有效率为94.03%。治疗后视觉模拟评分法(VAS)评分为(4.23±1.47)分,明显低于治疗前的(7.46±3.58)分(P<0.05)。本组患者未见严重并发症,仅11例出现轻度恶心、呕吐、便秘以及嗜睡症状,均可自行缓解。结论芬太尼透皮贴用于癌性疼痛的治疗效果较为显著,且不良反应发生情况较少,具有临床参考价值。
Objective To study the efficacy of transdermal fentanyl in patients with clinical cancer pain. Methods Sixty-seven patients with malignant tumors were treated with transdermal fentanyl. All the patients were initially treated with 25 μg / h of initial dose and once every 72 hours. According to the patient’s previous morphine application, The drug dose was adjusted until the desired analgesic effect was achieved. After 15 days of continuous treatment, the clinical efficacy was analyzed. The pain symptom scores were compared before and after treatment, and the incidence of adverse drug reactions was observed. Results After treatment, the group of 39 patients markedly effective, 24 were effective, 4 were ineffective, the total effective rate of pain relief was 94.03%. Visual analogue scale (VAS) score after treatment was (4.23 ± 1.47) points, which was significantly lower than that before treatment (7.46 ± 3.58) (P <0.05). This group of patients without serious complications, only 11 cases of mild nausea, vomiting, constipation and lethargy symptoms, can be relieved. Conclusion Transdermal fentanyl for the treatment of cancer pain is more effective, and the occurrence of adverse reactions less, with clinical reference value.