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目的调查未接受高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)的HIV/AIDS患者血清隐球菌抗原的阳性率。方法回顾性调查我院感染科2012年1—9月住院的77例未接受HAART的HIV/AIDS患者外周血CD4+T淋巴细胞计数及血清隐球菌抗原阳性率,比较隐球菌抗原阳性患者与阴性患者的CD4+T淋巴细胞计数。结果 77例(男53例,女24例)中,血清隐球菌抗原阳性48例,阳性率为62.34%,阴性29例,阴性率为37.66%。其中,CD4+T淋巴细胞计数≤50个/mm3的患者血清隐球菌抗原阳性率为72.73%。血清隐球菌抗原阳性患者外周血CD4+T淋巴细胞计数显著低于阴性患者(P=0.022)。结论未接受HAART的外周血CD4+T淋巴细胞计数较低的HIV/AIDS患者血清隐球菌抗原阳性率高,血清隐球菌抗原阳性患者CD4+T淋巴细胞水平低于阴性患者(P<0.05)。
Objective To investigate the positive rate of serum cryptococcal antigen in HIV / AIDS patients who did not receive highly active antiretroviral therapy (HAART). Methods Retrospectively investigated the CD4 + T lymphocyte counts and the positive rate of cryptococcal antigen in peripheral blood of 77 HIV / AIDS patients who did not receive HAART from January 2012 to January 2012 in our hospital. The patients with cryptococcal antigen positive and negative Patient’s CD4 + T lymphocyte count. Results Among the 77 cases (53 males and 24 females), 48 cases were positive for cryptococcal antigen, the positive rate was 62.34% and the negative rate was 29, the negative rate was 37.66%. Among them, the positive rate of serum cryptococcal antigen in patients with CD4 + T lymphocyte count ≤50 / mm3 was 72.73%. The counts of CD4 + T lymphocytes in peripheral blood of patients with positive Cryptococcus neoformans antigen were significantly lower than those of negative patients (P = 0.022). Conclusion The positive rate of Cryptococcus neoformans antigen in HIV / AIDS patients with low CD4 + T lymphocyte count in peripheral blood without HAART is high, and the level of CD4 + T lymphocytes in patients with positive Cryptococcus antigen is lower than that in negative patients (P <0.05).