口服避孕药是当前开展计划生育广泛应用的有效措施之一。据文献报导,目前全世界大约有8千万妇女服用甾体类避孕药。长期连续服用此类药物,对妇女自身和其后代是否具有潜在的影响,已引起人们的重视和深入的研究。例如,在高血压、糖代谢、血栓症以及致癌性等方面都已有不少的研究报告。但是在遗传效应方面的报导却远不及前者多,从细胞水平看,染色体是遗传物质基础的主要载体。染色体发生变化,将导致细胞物 Oral contraceptives is currently one of the effective measures to carry out family planning widely. According to the literature, about 80 million women in the world currently take steroid-based birth control pills. Long-term continuous use of such drugs has a potential impact on women themselves and their offspring, has attracted people’s attention and in-depth study. For example, there have been many reports on hypertension, glucose metabolism, thrombosis and carcinogenicity. However, the reports on the genetic effects are far less than the former, and from the cellular level, the chromosomes are the main carriers of the genetic material. Chromosome changes, will lead to cellular material