【摘 要】
：
Nitrogen-containing motifs are widely present in natural products,bioactive molecules,and drugs.Accordingly,effective synthetic methods with high efficiency and diversity are highly desirable.Here,we present the invention of a facile,visible light-mediate
【机 构】
：
Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University),State Key La
论文部分内容阅读
Nitrogen-containing motifs are widely present in natural products,bioactive molecules,and drugs.Accordingly,effective synthetic methods with high efficiency and diversity are highly desirable.Here,we present the invention of a facile,visible light-mediated decarboxylative C(sp3)-N bond-forming reaction by employing abundant carboxylic acids as the feedstock and a commercial diazirine as a nitrogen donor.This process is amenable to access both imines and diaziridines,as the corresponding masked amines and hydrazines,through a selectable single or double nitrogen transfer from the diazirine,respectively.This divergent approach works well in both directions with various alkyl carboxylic acids,including primary,secondary,and tertiary acids,as well as natural products and drugs,thus affording a rapid,metal-free approach to build nitrogen-containing molecule libraries with considerable structural diversity,which could thus benefit the related study in context of chemical biology and drug discovery.
其他文献
A bulk heterojunction in organic solar cells is where charge separation and recombination occur.Molecular orientation at the interface is one of the key factors that dictate solar cell efficiency.Although X-ray scattering-based methods can determine donor
Metal sulfides have been widely investigated as promising electrode materials for potassium-ion batteries(PIBs)due to their high theoretical capacities.However,the practical application of metal sulfides in PIBs is still hindered by their intrinsic shortc
A novel photoinduced intermolecular 1,2-arylheteroarylation of alkenes and the efficient synthesis of valuable polyarylalkanes are reported.The reaction is operationally simple,proceeds under mild conditions and with no additional catalyst and reagents.Th
Carbon dots (CDs),as a kind of carbon nanomaterials,have attracted widespread attention due to their unique structure and excellent optical properties,and they are low-cost,environmentally friendly and biocompatible.However,the development of near-infrare
Isolation of E-1,2-bis(4-bromophenyl)-1,2-diphenyl-ethylene from the E/Z isomer mixture obtained by a McMurry coupling reaction and reaction of this isomer with imidazole followed by N-alkylation with nBuBr and anion exchange yielded the bisimidazolium te
Flavin-dependent halogenases(FDHs)are well known to introduce carbon halide bonds(mainly C-Cl and C-Br)into natural products with the assistance of a partner protein flavin reductase to generate reduced flavin(FADH2 or FMNH2).Compared with the common chlo
Atomic sites co-catalyst(ASC)on photocatalytic materials possesses an attractive prospect to promote charge carrier separation and tune surface reaction kinetics,yet the synthesis of earth-abundant ASC under low temperature remains a great challenge.Here,
Open metal site(OMS)seated in a luminescent lanthanide(Ln)metal center offers an opportunity for rationally tuning the spectroscopic behavior of lanthanide-organic frameworks aiming for a wide range of sensing applications.However,given the spherical natu
Tiacumicin B(also known as fidaxomicin or difimicin)is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections.Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic ring,wh
Catalytic generation of cobalt enolates through ring-opening of easily accessible cyclopropanols,subsequent β-hydride elim-ination and site-selective reinsertion followed by diastereo-and enantioselective additions to aldimines is presented.Such a process