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目的观察脑外伤患者采用血液稀释加川芎嗪治疗前后血浆内皮素、血液粘滞度及临床疗效的变化。方法将重度脑外伤患者（ＧＣＳ＜８分）随机分为对照组（常规治疗）和治疗组。观察治疗前和治疗后３ｄ、１０ｄ、３周血浆内皮素、血液粘滞度及ＧＣＳ变化及ＧＯＳ。结果重度脑外伤患者伤后早期血浆内皮素和血液粘滞度增加。扩容治疗组患者治疗后血浆内皮素和血液粘滞度下降（Ｐ＜０．０５）。结论应用扩充血容量和川芎嗪联合治疗，能降低脑外伤患者血浆内皮素含量和血液粘滞度，降低死亡率。
Objective To observe the changes of plasma endothelin, blood viscosity and clinical curative effect of patients with traumatic brain injury treated with hemodilution and ligustrazine before and after treatment. Methods Patients with severe traumatic brain injury (GCS <8 points) were randomly divided into control group (conventional treatment) and treatment group. The changes of plasma endothelin, blood viscosity, GCS and GOS before and 3 days, 10 days and 3 weeks after treatment were observed. Results Patients with severe traumatic brain injury in early post-injury plasma endothelin and blood viscosity increased. After treatment, the plasma endothelin and blood viscosity decreased in the treatment group (P <0.05). Conclusions The combination of extended volume of blood volume and ligustrazine can reduce the plasma endothelin level and blood viscosity in patients with traumatic brain injury and reduce the mortality rate.