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目的探讨肝硬化患者发生医院感染的危险因素,提出相应对策,为感染的预防提供客观依据。方法选取2008年1月-2011年12月212例肝硬化患者作为研究对象,统计医院感染发生情况,将医院感染患者作为观察组,未发生医院感染患者作为对照组,对两组临床资料进行回顾性分析比较。结果 212例患者中47例发生医院感染,感染率为22.17%;主要为呼吸道与腹腔感染,其中肺部感染22例占46.81%;腹腔感染13例占27.66%;胆道及消化道感染7例占14.89%;泌尿感染与胸腔感染各2例,各占4.26%;口腔感染1例占2.13%;两组患者年龄、住院时间、肝功能、侵入性操作方面差异有统计学意义(P<0.05),在抗菌药物应用方面差异无统计学意义。结论高龄、住院时间长、肝功能差、侵入性操作等是肝硬化发生医院感染的危险因素,应在明确各种感染危险因素的基础上,针对性地采取措施预防肝硬化患者医院感染的发生。
Objective To explore the risk factors of nosocomial infection in cirrhotic patients and to put forward corresponding countermeasures to provide an objective basis for the prevention of infection. Methods A total of 212 patients with cirrhosis from January 2008 to December 2011 were enrolled in this study. The incidence of nosocomial infections was calculated. The patients with nosocomial infection were selected as the observation group and the patients without nosocomial infection as the control group. The clinical data of the two groups were reviewed Sex analysis and comparison. Results Of the 212 patients, 47 cases had nosocomial infection with a rate of 22.17%. The main respiratory tract and abdominal cavity infections were pulmonary infection in 22 cases (46.81%), abdominal infection in 13 cases (27.66%), biliary tract and gastrointestinal infection in 7 cases 14.89%; 2 cases of urinary tract infection and thoracic infection, each accounting for 4.26%; 1 case of oral infection accounted for 2.13%; There were significant differences in age, hospitalization time, liver function and invasiveness between the two groups (P <0.05) , No significant difference in the application of antibacterial drugs. Conclusions The elderly, long hospital stay, poor liver function and invasive operation are the risk factors of nosocomial infection in cirrhosis. On the basis of identifying the risk factors of various cirrhosis, we should take some measures to prevent the occurrence of nosocomial infection in patients with cirrhosis .