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目的：探讨经直肠超声引导下前列腺穿刺活检的临床应用价值。方法：回顾性分析经直肠超声引导下前列腺穿刺活检143例患者的临床、超声和病理资料。结果：①143例患者中，穿刺活检病理诊断为前列腺癌72例（占50.3%），前列腺增生43例（占30.1%），前列腺上皮内瘤28例（占19.6%）。②随着血清前列腺特异性抗原的升高，前列腺癌阳性检出率增加，且P S A水平越高，前列腺癌分级级别越高（P＜0.01）。结论：经直肠超声引导下前列腺穿刺活检有助于提高前列腺癌的早期诊断率。“,”Objective To investigate Clinical application value of transrectal ultrasound guided Biopsy of the prostate.MethodsThe data of clinic and the sonography and pathology were analyzed retrospectively in 143 patients who were underwent transcrectal ultrasound guided biopsy of the prostate.Results① In 143 cases,proved by biopsy prostate cancer in 72(50.3%),hyperplasia of prostate in 43(30.1%), prostatic intraepithelial neoplasm in 28(19.6%).② With the level of blood serum prostate specific antigen heightened,the positive rate of prostate cancer increased,and with the lever higher,grade of prostate cancer were higher(P<0.01).ConclusionTranscrectal ultrasound guided biopsy of the prostate is beneficial to diagnose prostate cancer of early stage.