目的探讨高通量血液透析(HFHD)对尿毒症患者血清磷(P)及高敏C反应蛋白(hs-CRP)、白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TRF)的影响。方法选取本院2015年2月至2017年1月期间收治的172例尿毒症患者,随机平均分为观察组86例和对照组86例,观察组患者采用HFHD治疗,对照组患者采用常规血液透析方法治疗,观察两组患者治疗前后P、hs-CRP、ALB、PA、TRF的变化情况,比较治疗后的营养状态和并发症发生情况。结果观察者患者治疗后的P、hs-CRP水平明显低于对照组,而ALB、PA、TRF水平显著高于对照组患者;同时观察组治疗后营养状态明显优于对照组,差异均具有统计学意义(P<0.05)。对照组患者治疗后感染、心血管疾病及皮肤瘙痒发生率均显著高于观察组患者,差异具有统计学意义(P<0.05)。结论 HFHD能够显著降低患者P及hs-CRP水平同时提高ALB、PA、TRF水平,帮助机体正常代谢,有效改善机体炎症及营养状态,是尿毒症患者更佳治疗方式。 Objective To investigate the effects of high-throughput hemodialysis (HFHD) on serum phosphorus (P) and high-sensitivity C reactive protein (hs-CRP), albumin (ALB), prealbumin (PA), transferrin (TRF) influences. Methods A total of 172 uremic patients admitted from February 2015 to January 2017 in our hospital were randomly divided into observation group (86 cases) and control group (86 cases). Patients in the observation group were treated with HFHD. Patients in the control group were treated with routine hemodialysis Methods The changes of P, hs-CRP, ALB, PA and TRF in two groups before and after treatment were observed. The nutritional status and complications after treatment were compared. Results After treatment, the levels of P and hs-CRP in the observers were significantly lower than those in the control group, while the levels of ALB, PA and TRF in the observation group were significantly higher than those in the control group. At the same time, the nutritional status of the observation group was significantly better than that of the control group Significance (P <0.05). The incidence of infection, cardiovascular disease and pruritus in the control group were significantly higher than those in the observation group after treatment, the difference was statistically significant (P <0.05). Conclusion HFHD can significantly reduce the level of P and hs-CRP in patients with elevated serum levels of ALB, PA and TRF, help normal metabolism, and effectively improve the inflammation and nutritional status of the body. It is a better treatment for patients with uremia.