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目的了解人乳头状瘤病毒(HPV)16/18型感染与乳腺癌关系,为乳腺癌预防及诊治工作提供依据。方法对医院2011~2012年住院患者手术切除的120份乳腺组织进行分析,采用原位杂交法检测HPV16、HPV18在乳腺癌、乳腺纤维腺瘤瘤组织及正常乳腺组织中的表达。结果 50例乳腺癌患者HPV 16/18DNA阳性率为58.00%,高于乳腺纤维腺瘤组的20.00%和正常乳腺组织组的14.29%,差异均有统计学意义(χ2=12.177,16.393,P均<0.05)。浸润性导管癌、浸润性小叶癌及其他型别乳腺癌HPV 16/18DNA阳性率分别为60.71%、56.25%和50.00%,差异无统计学意义(χ2=0.084,P>0.05)。有腋淋巴结转移的乳腺癌HPV 16/18DNA阳性率(68.75%)远高于无腋淋巴结转移的乳腺癌(38.89%)(χ2=4.217,P<0.05)。结论 HPV16/18型感染与乳腺癌间存在一定的相关性,但作用机制有待于进一步研究。
Objective To understand the relationship between human papillomavirus (HPV) 16/18 infection and breast cancer and provide the basis for the prevention and treatment of breast cancer. Methods 120 cases of surgical resection of inpatients from 2011 to 2012 in our hospital were analyzed. In situ hybridization was used to detect the expression of HPV16 and HPV18 in breast cancer, fibroadenoma of breast and normal breast tissues. Results The positive rate of HPV 16/18 DNA in 50 cases of breast cancer was 58.00%, higher than that of 20.00% in breast fibroadenoma group and 14.29% in normal breast tissue group (χ2 = 12.177, 16.393, P <0.05). The positive rates of HPV 16/18 DNA in invasive ductal carcinoma, invasive lobular carcinoma and other types of breast cancer were 60.71%, 56.25% and 50.00% respectively, with no significant difference (χ2 = 0.084, P> 0.05). The positive rate of HPV 16/18 DNA in breast cancer with axillary lymph node metastasis (68.75%) was significantly higher than that in non-axillary lymph node metastasis (38.89%) (χ2 = 4.217, P <0.05). Conclusion There is a certain correlation between HPV16 / 18 infection and breast cancer, but the mechanism remains to be further studied.