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饰胶蛋白聚糖 (decorin ,DCN)是一种富含亮氨酸的小分子蛋白聚糖 (SLRPs) ,普遍存在于ECM中。DCN能调节胶原合成 ;能与fibronectin (FN)和thrombospondin 1 (TSP 1 )结合 ,参与调节细胞的增生、迁移 ;并能中和TGF β活性及作为TGF β活性的一种负反馈调节因子。近来发现可以利用DCN中和TGF β活性、减轻ECM沉积这一特性治疗肾脏疾病。
Decorin (DCN) is a leucine-rich small molecule proteoglycan (SLRPs) that is commonly found in ECM. DCN regulates collagen synthesis; binds to fibronectin (FN) and thrombospondin 1 (TSP 1) and regulates cell proliferation and migration; and neutralizes TGF β activity and acts as a negative feedback regulator of TGF β activity. Recently found that the use of DCN can neutralize TGF β activity, reduce the deposition of ECM this feature of kidney disease.