据报道3%乙酰半胱氨酸(以下简称 AC)滴眼液,用磷酸盐缓冲液调至 pH6.9,在冷暗处长期保存,其药理效果不变。但有的文献记载 AC 的水溶液不稳定,且多种金属(特别是铜、铁)、橡胶、氧和氧化性物质均能促进其失效。为了考查和制备较稳定的 AC 滴眼液,特进行了如下实验。 It has been reported that 3% acetylcysteine ​​(hereinafter referred to as AC) eye drops, adjusted to pH6.9 with phosphate buffer, long-term preservation in the dark, the pharmacological effects remain unchanged. However, it has been documented in literature that aqueous solutions of AC are unstable and that many kinds of metals, particularly copper and iron, rubber, oxygen and oxidizing substances can promote their failure. In order to examine and prepare a more stable AC eye drops, the following experiments were carried out.