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目的观察盐酸沙格雷酯治疗血栓闭塞性脉管炎(TAO)的疗效。方法采用盐酸沙格雷酯治疗TAO患者81例,每例患者均口服盐酸沙格雷酯片100mg/次,3次/d,服用3个月,观察患者的临床表现。结果治疗后对患者间歇性跛行改善总有效率为87.7%(57/65),疼痛改善总有效率为94.9%(74/78),冷感改善总有效率为97.2%(69/71),溃疡改善总有效率94.1%(32/34);但比较治疗前后患者的血常规及凝血指标变化差异无统计学意义(P均>0.05)。结论盐酸沙格雷酯治疗TAO疗效显著,安全可靠。
Objective To observe the efficacy of sarpogrelate hydrochloride in the treatment of thromboangiitis obliterans (TAO). Methods 81 patients with TAO were treated with sarpogrelate hydrochloride. Each patient was given oral sarpogrelate 100 mg once daily for 3 months for observation of the clinical manifestations. Results After treatment, the total effective rate of patients with intermittent claudication was 87.7% (57/65), the total effective rate of pain improvement was 94.9% (74/78), the total effective rate of cold feeling improvement was 97.2% (69/71) The total effective rate of ulcer improvement was 94.1% (32/34). However, there was no significant difference between the two groups in blood routine and coagulation index before and after treatment (P> 0.05). Conclusion Sarigrette hydrochloride treatment of TAO significant effect, safe and reliable.