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目的:研究对幽门螺杆菌(Hp)相关性消化性溃疡的Hp根除、溃疡愈合及溃疡复发的关系。方法:113例诊断为Hp感染者中DU86例、GU27例。对上述病例随机分为两组给药:A组:奥美拉唑20mg1次/日+阿莫西林500mg4次/日+甲硝唑400mg3次/日;B组:雷尼替丁300mg1次/晚+阿莫西林500mg4次/日+甲硝唑400mg3次/日。两组抗Hp治疗均为2周,其后奥美拉唑、雷尼替丁再用2周,疗程共4周。于治疗后1个月、疗程结束后1个月、6个月、1年及2年复查胃镜及Hp,观察溃疡复发及Hp再感染情况。对症状再发者随时复查胃镜。结果:在Hp根除的70例DU患者中,2年共复发12例(17.1％),Hp未根除的16例DU患者中,2年共复发10例(62.5％)。两组相比,P<0.01,差异有特别显著意义。Hp根除的21例GU患者中,2年共复发5例(23.8％)。Hp未根除的6例GU患者中,2年共复发3例(50％)。两组相比,P<0.05,差异有显著性。除1例复发DU外,其余复发的DU和GU,均为Hp再感染者。
Objective: To study the relationship between Hp eradication, ulcer healing and ulcer recurrence in Helicobacter pylori (Hp) -related peptic ulcer. Methods: 113 cases were diagnosed as Hp infection in DU86 cases, GU27 cases. The above cases were randomly divided into two groups: A group: omeprazole 20mg1 times / day + amoxicillin 500mg4 times / day + metronidazole 400mg3 times / day; B group: ranitidine 300mg1 times / night + Amoxicillin 500mg4 times / day + metronidazole 400mg3 times / day. Two groups of anti-Hp treatment were 2 weeks, followed by omeprazole, ranitidine and then 2 weeks, a total of 4 weeks. Gastroscope and Hp were observed at 1 month, 1 month, 6 months, 1 year and 2 years after the end of treatment, and the recurrence of ulcer and re-infection of Hp were observed. The recurrence of symptoms at any time review of gastroscopy. Results: Of the 70 DU patients with Hp eradication, 12 cases (17.1%) were relapsed in 2 years and 10 cases (62.5%) were relapsed in 2 years in 16 cases of DU patients without Hp eradication. Compared with the two groups, P <0.01, the difference has a special significance. Among the 21 patients with Hp eradication, 5 patients (23.8%) relapsed after 2 years. Of the 6 GU patients who did not have Hp eradication, 3 (50%) relapsed after 2 years. Compared with the two groups, P <0.05, the difference was significant. In addition to 1 case of relapsed DU, the rest of the DU and GU relapse were re-infected with Hp.