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目的:研究“三仙”不同炮制品对小鼠胃肠运动抑制的影响。方法:采用半固体糊推进法,以小鼠的胃内相对残留率和小肠推进率为指标,分别观察“三仙”不同炮制品对硫酸阿托品和多巴胺所致胃肠抑制模型小鼠胃排空及小肠推进运动的影响。结果:对硫酸阿托品所致小鼠小肠推进抑制的影响:与模型组相比,“三仙”生品高、中剂量组有统计学意义(P<0.05),其余各组具有推进的趋势;胃排空抑制的影响:与模型组比较,“三仙”生品中剂量组、炒品中、低剂量组具有统计学意义(P<0.05);对多巴胺所致小鼠小肠推进和胃排空抑制的影响:与模型组比较,“三仙”生品、炒品、焦品各剂量组均无统计学意义(P>0.05),仅具有推进的趋势。结论:“三仙”不同炮制品对硫酸阿托品所致的小鼠胃肠抑制具有不同程度的改善作用,以“生三仙”最显著;对盐酸多巴胺所致的小鼠胃肠抑制不具有改善作用。
Objective: To study the effects of different processed products of “Sanxian” on gastrointestinal motility in mice. Methods: The semi-solid paste method was used to observe the relative gastric residual rate and small intestine propulsion rate in mice. The effect of different processed products of “Sanxian” on gastrointestinal inhibitory model mice stomach caused by atropine sulfate and dopamine Emptying and small bowel movement. Results: The effect of atropine sulfate on small intestine propulsion in mice: Compared with the model group, the high and medium dose group of “Sanxian” had statistical significance (P <0.05), and the others had the promotion (P <0.05). The effect of gastric emptying inhibition: compared with the model group, the “Sanxian” medium-dose group, the medium-dose and the low-dose group had significant difference Advancing and inhibiting gastric emptying: compared with the model group, the “Sanxian” raw, fried, coke products of each dose group were not statistically significant (P> 0.05), only with the promotion trend. CONCLUSION: The different processed products of “Sanxian” can improve the gastrointestinal inhibition of mice induced by atropine sulfate to some extent, and the most significant is “San Sanxian”; the gastrointestinal Suppression does not improve.