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目的:观察小儿乙肝颗粒对肝纤维化的防治作用。方法:采用四氯化碳(CCl_4)大鼠慢性肝损害模型,观察小儿乙肝颗粒对大鼠免疫复合物(CIC)、淋巴细胞转化率(LTR)、透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原肽(PⅢP)及肝功能的影响,并作光镜病理学观察。结果:小儿乙肝颗粒能提高肝纤维化大鼠血清Alb、LTR,降低血清G、CIC及肝纤维化指标HA、LN、PⅢP的数值,改善肝组织病理损害,其中在改善ALB、G、CIC、PⅢP、LN值及病理损害方面均明显优于秋水仙碱组(P<0.05～0.01)。其余几项指标与秋水仙碱组相比无显著性差异。结论:小儿乙肝颗粒具有确切的抗肝纤维化效果。
OBJECTIVE: To observe the preventive and therapeutic effects of Pediatric B-kidney granules on hepatic fibrosis. METHODS: Chronic hepatic impairment model in rats with carbon tetrachloride (CCl_4) was used to observe the effects of pediatric hepatitis B particles on rat immune complex (CIC), lymphocyte transformation rate (LTR), hyaluronic acid (HA), laminin ( LN), type III procollagen peptide (PIIIP) and hepatic function, and light microscope pathological observation. RESULTS: Pediatric hepatitis B granules could increase serum Alb, LTR in liver fibrosis rats, reduce serum G, CIC and hepatic fibrosis indexes HA, LN, and PIIIP, and improve liver pathological damage, among which ALB, G, and CIC were improved. PIIIP, LN values and pathological lesions were significantly better than colchicine group (P<0.05-0.01). The other indicators were not significantly different from the colchicine group. Conclusion: Pediatric hepatitis B granules have the exact anti-fibrotic effect.