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目的 探讨IGF Ⅰ 在肾癌组织中的表达状况。方法 采用RT PCR方法检测 2 5例肾癌及其癌周组织IGF ⅠmRNA的表达。结果 2 5例肾癌组织中 ,IGF ⅠmRNA无表达 2例 ,低表达 13例 ,中等表达 10例 ;癌旁组织无表达 8例 ,低表达 13例 ,中等表达 4例。癌组织表达强度明显高于癌周组织 (P <0 .0 5 )。 16例Ⅰ、Ⅱ期癌 ,IGF ⅠmRNA无表达 2例 ,低表达 11例 ,中等表达 3例 ;9例Ⅲ、Ⅳ期癌 ,低表达 2例 ,中等表达 7例。Ⅲ、Ⅳ期癌表达强度明显高于Ⅰ、Ⅱ期癌 (P <0 .0 5 )。结论 IGF Ⅰ能够促进肾癌细胞的转移
Objective To investigate the expression of IGF Ⅰ in renal cell carcinoma. Methods RT - PCR was used to detect the expression of IGF Ⅰ mRNA in 25 cases of renal cell carcinoma and its peritumoral tissues. Results There was no expression of IGF Ⅰ mRNA in 2 cases, low expression of 13 cases and moderate expression in 25 cases of renal cell carcinoma. There were 8 cases with no expression of IGF Ⅰ, 13 cases with low expression and 4 cases with moderate expression. The expression intensity of cancer tissue was significantly higher than that of peritumorous tissue (P <0.05). In 16 cases of stage Ⅰ and Ⅱ cancer, IGF Ⅰ mRNA was not expressed in 2 cases, low expression in 11 cases, moderate expression in 3 cases, and in 9 cases of stage Ⅲ and Ⅳ carcinoma, 2 cases were low expression and 7 cases were moderate expression. The expression of stage III and stage IV cancer was significantly higher than that of stage I and stage II cancer (P <0.05). Conclusion IGF Ⅰ can promote the metastasis of renal cell carcinoma